New research reveals that individuals who come off new slimming jabs like semaglutide or tirzepatide tend to recover shed pounds far faster than those who end conventional lifestyle programs.
Findings released in a major health publication demonstrates that while overweight people can lose substantial amounts of their body weight while on the medication, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"Individuals using such treatments need to be aware of the potential of quick rebound weight gain when the treatment concludes," warns expert Dr. Susan Jebb.
That rate of regain suggests a reversion to pre-treatment weight within about one and a half years.
Comparing Therapies
The research, which examined 37 of trials involving over 9,000 of participants, contrasted the effects of the injectable medications with other pills.
The team emphasize that people who lose weight through lifestyle changes alone usually see a less rapid creep back—around 0.1 kg a month—post-intervention.
The Reason for the Quick Rebound
Experts suggest the way of the injections explains the accelerated weight return.
These medications mimic a natural hormone called GLP-1, which controls feelings of fullness.
"Artificially providing the hormone concentrations far above than the body's typical production may cause the body to generate a reduced amount of its endogenous GLP-1, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication results in hunger is uncontrolled, making binge eating much more probable."
An Ongoing Issue?
Health authorities recommend the injections for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians say that, considering the high risk of relapse, the therapy might need to be long-term.
This opinion is reinforced by pharmaceutical companies, who state that the findings "emphasize the persistent nature of excess weight," comparing it to managing conditions like diabetes.
Patient Experiences
Individuals who have stopped the medication describe a powerful resurgence of hunger.
"It was like a trigger flipping and you're instantly ravenous," said one woman.
The struggle is worsened if individuals have not established lasting dietary or behavioural modifications during therapy.
Growing Interest
Figures show that a significant number of adults in the UK have used weight-loss jabs in the past year, with interest being substantial.
- Use is more common among women compared to males.
- The 40s and 50s age group shows the highest level of interest.
- Many access the medications through private prescriptions rather than public health services.
Finally, experts stress that while these medications are powerful tools for weight loss, they are not a permanent cure and long-term success likely depends on ongoing lifestyle changes.
